Drug interactions
Remifentanil + Valerian
Severity: Moderate
Remifentanil and Valerian: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valerian has mild sedative properties that may add to the effects of a potent opioid. Clinical data are limited, but additive drowsiness is plausible.
What this interaction means in plain words
Remifentanil and Valerian can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression, probably through GABAergic activity of valerian.
What to do
Ask about herbal use before anesthesia or opioid therapy, and monitor sedation. Advise stopping valerian before procedures.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Remifentanil
- Alvimopan + Remifentanil Contraindicated
- Isocarboxazid + Remifentanil Contraindicated
- Olanzapine / samidorphan + Remifentanil Contraindicated
- Phenelzine + Remifentanil Contraindicated
- Benzhydrocodone / acetaminophen + Remifentanil Major
- Brexanolone + Remifentanil Major
Frequently asked questions
Can I take Remifentanil with Valerian?
MediHelp rates the interaction as moderate. Remifentanil and Valerian can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valerian has mild sedative properties that may add to the effects of a potent opioid. Clinical data are limited, but additive drowsiness is plausible.
How serious is the interaction between Remifentanil and Valerian?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask about herbal use before anesthesia or opioid therapy, and monitor sedation. Advise stopping valerian before procedures.
What other medicines interact with Remifentanil?
MediHelp also lists interactions of Remifentanil with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Remifentanil page.
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