Drug interactions
Rho human immunoglobulin + Rubella vaccine
Severity: Moderate
Rho human immunoglobulin and Rubella vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Passive antibodies from Rho(D) immune globulin may neutralize live rubella vaccine virus and weaken the immune response. This matters in postpartum women who need rubella immunity.
What this interaction means in plain words
Rho human immunoglobulin and Rubella vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Passively acquired antibodies neutralize replication of the live vaccine virus.
What to do
If rubella vaccine is given postpartum with Rho(D) immune globulin, confirm seroconversion after about 3 months and revaccinate if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Rho human immunoglobulin with Rubella vaccine?
MediHelp rates the interaction as moderate. Rho human immunoglobulin and Rubella vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Passive antibodies from Rho(D) immune globulin may neutralize live rubella vaccine virus and weaken the immune response. This matters in postpartum women who need rubella immunity.
How serious is the interaction between Rho human immunoglobulin and Rubella vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If rubella vaccine is given postpartum with Rho(D) immune globulin, confirm seroconversion after about 3 months and revaccinate if needed.
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