Drug interactions
Rho human immunoglobulin + Varicella virus vaccine live
Severity: Moderate
Rho human immunoglobulin and Varicella virus vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Passive antibodies in Rho(D) immune globulin may reduce the immune response to live varicella vaccine. Protection may be incomplete.
What this interaction means in plain words
Rho human immunoglobulin and Varicella virus vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Passively acquired antibodies neutralize replication of the live vaccine virus.
What to do
Consider delaying varicella vaccination for about 3 months after Rho(D) immune globulin, or confirm immunity afterward.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Rho human immunoglobulin with Varicella virus vaccine live?
MediHelp rates the interaction as moderate. Rho human immunoglobulin and Varicella virus vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Passive antibodies in Rho(D) immune globulin may reduce the immune response to live varicella vaccine. Protection may be incomplete.
How serious is the interaction between Rho human immunoglobulin and Varicella virus vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider delaying varicella vaccination for about 3 months after Rho(D) immune globulin, or confirm immunity afterward.
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