Drug interactions
rifampin + ritonavir-boosted atazanavir
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Overview
Loss of virologic control/hepatotoxicity; contraindicated.
Mechanism of action
Potent CYP3A induction.
Clinical management
Contraindicated; use rifabutin if needed.
References
Frequently asked questions
Can I take rifampin with ritonavir-boosted atazanavir?
The interaction is rated: Contraindicated. Loss of virologic control/hepatotoxicity; contraindicated.
How serious is the interaction between rifampin and ritonavir-boosted atazanavir?
The interaction is rated: Contraindicated. Evidence level: High.
How is the interaction between rifampin and ritonavir-boosted atazanavir managed?
Contraindicated; use rifabutin if needed.
Why do rifampin and ritonavir-boosted atazanavir interact?
Potent CYP3A induction.
Full monographs, dosing and an interaction checker in the MediHelp app
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