Drug interactions
Rifaximin + Ulipristal
Severity: Minor
Rifaximin and Ulipristal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ulipristal may inhibit intestinal P-glycoprotein and slightly increase rifaximin absorption. Clinical relevance is likely low because rifaximin systemic exposure is minimal.
What this interaction means in plain words
Rifaximin and Ulipristal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible P-glycoprotein inhibition by ulipristal reduces rifaximin efflux.
What to do
No action is generally needed. Monitor for rifaximin adverse effects if hepatic function is severely impaired.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rifaximin
- Cholera vaccine + Rifaximin Major
- Microbiota + Rifaximin Major
- Amiodarone + Rifaximin Moderate
- Bcg intravesical live + Rifaximin Moderate
- Cyclosporine + Rifaximin Moderate
- Cyclosporin + Rifaximin Moderate
Frequently asked questions
Can I take Rifaximin with Ulipristal?
MediHelp rates the interaction as minor. Rifaximin and Ulipristal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ulipristal may inhibit intestinal P-glycoprotein and slightly increase rifaximin absorption. Clinical relevance is likely low because rifaximin systemic exposure is minimal.
How serious is the interaction between Rifaximin and Ulipristal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed. Monitor for rifaximin adverse effects if hepatic function is severely impaired.
What other medicines interact with Rifaximin?
MediHelp also lists interactions of Rifaximin with, for example, Cholera vaccine, Microbiota, Amiodarone. The full list is on the Rifaximin page.
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