Drug interactions
Romidepsin + Salbutamol
Severity: Moderate
Romidepsin and Salbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin can cause QT prolongation and ECG changes. Salbutamol may add to arrhythmic risk by lowering potassium and raising heart rate, especially at high doses.
What this interaction means in plain words
Romidepsin and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, with salbutamol-induced hypokalemia as a contributing factor.
What to do
Check potassium and magnesium before and during romidepsin treatment and correct deficits. Obtain an ECG if high-dose or frequent salbutamol is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Frequently asked questions
Can I take Romidepsin with Salbutamol?
MediHelp rates the interaction as moderate. Romidepsin and Salbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin can cause QT prolongation and ECG changes. Salbutamol may add to arrhythmic risk by lowering potassium and raising heart rate, especially at high doses.
How serious is the interaction between Romidepsin and Salbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium and magnesium before and during romidepsin treatment and correct deficits. Obtain an ECG if high-dose or frequent salbutamol is needed.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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