Drug interactions
Romidepsin + Venlafaxine
Severity: Moderate
Romidepsin and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin can cause ECG changes including QT prolongation, and venlafaxine may also prolong QT at higher doses or in overdose. Combined use may increase the risk of ventricular arrhythmia, especially with electrolyte disturbances.
What this interaction means in plain words
Romidepsin and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT interval prolongation.
What to do
Check baseline ECG and correct potassium and magnesium before and during romidepsin cycles. Monitor QTc and consider an alternative antidepressant if QTc is significantly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Romidepsin with Venlafaxine?
MediHelp rates the interaction as moderate. Romidepsin and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Romidepsin can cause ECG changes including QT prolongation, and venlafaxine may also prolong QT at higher doses or in overdose. Combined use may increase the risk of ventricular arrhythmia, especially with electrolyte disturbances.
How serious is the interaction between Romidepsin and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium and magnesium before and during romidepsin cycles. Monitor QTc and consider an alternative antidepressant if QTc is significantly prolonged.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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