Drug interactions
Ropeginterferon alfa 2b + Theophylline
Severity: Moderate
Ropeginterferon alfa 2b and Theophylline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Interferon alfa can raise theophylline concentrations, as seen with other interferons. Interferons also cause neuropsychiatric effects, which may add to the CNS stimulation of theophylline.
What this interaction means in plain words
Ropeginterferon alfa 2b and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Interferon alfa reduces CYP1A2-mediated clearance of theophylline, and both agents can have additive central nervous system effects.
What to do
Monitor theophylline serum levels and neuropsychiatric symptoms, and lower the theophylline dose if levels are elevated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Frequently asked questions
Can I take Ropeginterferon alfa 2b with Theophylline?
MediHelp rates the interaction as moderate. Ropeginterferon alfa 2b and Theophylline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Interferon alfa can raise theophylline concentrations, as seen with other interferons. Interferons also cause neuropsychiatric effects, which may add to the CNS stimulation of theophylline.
How serious is the interaction between Ropeginterferon alfa 2b and Theophylline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline serum levels and neuropsychiatric symptoms, and lower the theophylline dose if levels are elevated.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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