Drug interactions
Salbutamol + Yohimbine
Severity: Moderate
Salbutamol and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salbutamol and yohimbine both increase sympathetic activity. Together they may cause greater rises in heart rate and blood pressure, along with tremor, anxiety and palpitations.
What this interaction means in plain words
Salbutamol and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic stimulation: beta-2 agonism from salbutamol and alpha-2 antagonism with increased noradrenaline release from yohimbine.
What to do
Monitor blood pressure and heart rate, particularly in patients with cardiovascular disease or hypertension. Reduce or stop yohimbine if symptoms of sympathetic excess occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salbutamol
Frequently asked questions
Can I take Salbutamol with Yohimbine?
MediHelp rates the interaction as moderate. Salbutamol and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salbutamol and yohimbine both increase sympathetic activity. Together they may cause greater rises in heart rate and blood pressure, along with tremor, anxiety and palpitations.
How serious is the interaction between Salbutamol and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, particularly in patients with cardiovascular disease or hypertension. Reduce or stop yohimbine if symptoms of sympathetic excess occur.
What other medicines interact with Salbutamol?
MediHelp also lists interactions of Salbutamol with, for example, Arsenic trioxide, Carvedilol, Droperidol. The full list is on the Salbutamol page.
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