Drug interactions
Salicylates + Telmisartan-amlodipine
Severity: Moderate
Salicylates and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-acetylated salicylates have weaker prostaglandin inhibition than other NSAIDs but may still blunt the blood pressure effect of telmisartan. Renal function can worsen in volume-depleted or elderly patients.
What this interaction means in plain words
Salicylates and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of vasodilatory renal prostaglandins reduces renal perfusion and antagonizes angiotensin receptor blocker effects.
What to do
Monitor blood pressure and serum creatinine and potassium when salicylates are used regularly, and ensure adequate hydration. Prefer the lowest effective salicylate dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Frequently asked questions
Can I take Salicylates with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Salicylates and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Non-acetylated salicylates have weaker prostaglandin inhibition than other NSAIDs but may still blunt the blood pressure effect of telmisartan. Renal function can worsen in volume-depleted or elderly patients.
How serious is the interaction between Salicylates and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and serum creatinine and potassium when salicylates are used regularly, and ensure adequate hydration. Prefer the lowest effective salicylate dose.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
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