Drug interactions
Salsalate + Venlafaxine
Severity: Moderate
Salsalate and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is a salicylate NSAID that can irritate the gastrointestinal tract, and venlafaxine reduces platelet aggregation. Together they raise the risk of gastrointestinal bleeding, though salsalate has relatively weak platelet effects.
What this interaction means in plain words
Salsalate and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on platelet function and gastric mucosal integrity.
What to do
Use the lowest effective salsalate dose and consider a proton pump inhibitor in patients at high risk. Monitor for melena and anemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Salsalate with Venlafaxine?
MediHelp rates the interaction as moderate. Salsalate and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is a salicylate NSAID that can irritate the gastrointestinal tract, and venlafaxine reduces platelet aggregation. Together they raise the risk of gastrointestinal bleeding, though salsalate has relatively weak platelet effects.
How serious is the interaction between Salsalate and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective salsalate dose and consider a proton pump inhibitor in patients at high risk. Monitor for melena and anemia.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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