Drug interactions
Saquinavir + Ulipristal
Severity: Moderate
Saquinavir and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Saquinavir, usually given with ritonavir, inhibits CYP3A4 and may increase ulipristal levels. The consequences of higher exposure are not well defined.
What this interaction means in plain words
Saquinavir and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Saquinavir (with ritonavir) inhibits CYP3A4-mediated ulipristal metabolism.
What to do
Consider a copper IUD or alternative emergency contraceptive. If ulipristal is used, counsel on possible adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Saquinavir with Ulipristal?
MediHelp rates the interaction as moderate. Saquinavir and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Saquinavir, usually given with ritonavir, inhibits CYP3A4 and may increase ulipristal levels. The consequences of higher exposure are not well defined.
How serious is the interaction between Saquinavir and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a copper IUD or alternative emergency contraceptive. If ulipristal is used, counsel on possible adverse effects.
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