Drug interactions
Selegiline transdermal + Xylometazoline
Severity: Moderate
Selegiline transdermal and Xylometazoline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Xylometazoline is a topical nasal alpha agonist with limited systemic absorption, but labeling advises against use with MAO inhibitors because of possible pressor effects. The risk is lower than with oral sympathomimetics but hypertensive reactions are possible.
What this interaction means in plain words
Selegiline transdermal and Xylometazoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
MAO inhibition may potentiate adrenergic pressor effects of absorbed xylometazoline.
What to do
Prefer saline or non-adrenergic nasal therapy, and keep xylometazoline to the label dose and duration. Monitor blood pressure if used.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Xylometazoline
- Selegiline + Xylometazoline Contraindicated
- Ergotamine + Xylometazoline Major
- Isocarboxazid + Xylometazoline Major
- Phenelzine + Xylometazoline Major
- Tranylcypromine + Xylometazoline Major
- Amitriptyline + Xylometazoline Moderate
Frequently asked questions
Can I take Selegiline transdermal with Xylometazoline?
MediHelp rates the interaction as moderate. Selegiline transdermal and Xylometazoline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Xylometazoline is a topical nasal alpha agonist with limited systemic absorption, but labeling advises against use with MAO inhibitors because of possible pressor effects. The risk is lower than with oral sympathomimetics but hypertensive reactions are possible.
How serious is the interaction between Selegiline transdermal and Xylometazoline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer saline or non-adrenergic nasal therapy, and keep xylometazoline to the label dose and duration. Monitor blood pressure if used.
What other medicines interact with Xylometazoline?
MediHelp also lists interactions of Xylometazoline with, for example, Selegiline, Ergotamine, Isocarboxazid. The full list is on the Xylometazoline page.
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