Drug interactions
Sofosbuvir / velpatasvir + Tenofovir disoproxil
Severity: Moderate
Sofosbuvir / velpatasvir and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Velpatasvir increases tenofovir exposure, particularly when tenofovir disoproxil is given with a boosted HIV protease inhibitor or cobicistat. This raises the risk of renal and bone adverse effects.
What this interaction means in plain words
Sofosbuvir / velpatasvir and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Velpatasvir inhibits intestinal P-glycoprotein and BCRP, increasing tenofovir absorption.
What to do
Monitor for tenofovir-related adverse reactions, including renal function and phosphate; use caution with boosted regimens and consider alternatives if renal function declines.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Sofosbuvir / velpatasvir with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Sofosbuvir / velpatasvir and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Velpatasvir increases tenofovir exposure, particularly when tenofovir disoproxil is given with a boosted HIV protease inhibitor or cobicistat. This raises the risk of renal and bone adverse effects.
How serious is the interaction between Sofosbuvir / velpatasvir and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tenofovir-related adverse reactions, including renal function and phosphate; use caution with boosted regimens and consider alternatives if renal function declines.
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