Drug interactions
Streptozocin + Tenofovir disoproxil
Severity: Major
Streptozocin and Tenofovir disoproxil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Streptozocin commonly causes dose-related renal toxicity, and tenofovir disoproxil can cause proximal tubular injury and reduced renal function. Together the risk of serious kidney damage is increased.
What this interaction means in plain words
Streptozocin and Tenofovir disoproxil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxicity affecting the renal tubules.
What to do
Avoid the combination where possible, using a non-nephrotoxic antiretroviral alternative. If unavoidable, monitor serum creatinine, phosphate and urinalysis frequently and stop at signs of renal deterioration.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Frequently asked questions
Can I take Streptozocin with Tenofovir disoproxil?
MediHelp rates the interaction as major. Streptozocin and Tenofovir disoproxil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Streptozocin commonly causes dose-related renal toxicity, and tenofovir disoproxil can cause proximal tubular injury and reduced renal function. Together the risk of serious kidney damage is increased.
How serious is the interaction between Streptozocin and Tenofovir disoproxil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, using a non-nephrotoxic antiretroviral alternative. If unavoidable, monitor serum creatinine, phosphate and urinalysis frequently and stop at signs of renal deterioration.
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