Drug interactions
Sufentanil sl + Venlafaxine
Severity: Moderate
Sufentanil sl and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids such as sufentanil have weak serotonergic activity and combined with venlafaxine may rarely cause serotonin syndrome. Venlafaxine and opioids may also add to CNS effects.
What this interaction means in plain words
Sufentanil sl and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity.
What to do
Observe for agitation, clonus, hyperthermia and autonomic instability, particularly at initiation and dose changes. Stop the serotonergic agents if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Sufentanil sl and Venlafaxine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Sufentanil sl with Venlafaxine?
MediHelp rates the interaction as moderate. Sufentanil sl and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids such as sufentanil have weak serotonergic activity and combined with venlafaxine may rarely cause serotonin syndrome. Venlafaxine and opioids may also add to CNS effects.
How serious is the interaction between Sufentanil sl and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Observe for agitation, clonus, hyperthermia and autonomic instability, particularly at initiation and dose changes. Stop the serotonergic agents if serotonin syndrome is suspected.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
