Drug interactions
Sufentanil sl + Zolpidem
Severity: Major
Sufentanil sl and Zolpidem: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sublingual sufentanil combined with zolpidem raises the risk of profound sedation, respiratory depression, hypotension, coma and death.
What this interaction means in plain words
Sufentanil sl and Zolpidem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic CNS and respiratory depression via opioid receptors and GABA-A modulation.
What to do
Avoid unless alternatives are inadequate; limit dose and duration and monitor closely for respiratory depression and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Zolpidem
Frequently asked questions
Can I take Sufentanil sl with Zolpidem?
MediHelp rates the interaction as major. Sufentanil sl and Zolpidem can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sublingual sufentanil combined with zolpidem raises the risk of profound sedation, respiratory depression, hypotension, coma and death.
How serious is the interaction between Sufentanil sl and Zolpidem?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless alternatives are inadequate; limit dose and duration and monitor closely for respiratory depression and sedation.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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