Drug interactions
Telotristat ethyl + Theophylline
Severity: Minor
Telotristat ethyl and Theophylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Telotristat induces CYP3A4 and may reduce exposure to sensitive substrates. Theophylline relies mainly on CYP1A2, so the effect is likely small, though reduced efficacy is possible.
What this interaction means in plain words
Telotristat ethyl and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Induction of CYP3A4 by telotristat may increase minor hepatic pathways for theophylline.
What to do
Monitor asthma or COPD control and check a theophylline level if response declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Frequently asked questions
Can I take Telotristat ethyl with Theophylline?
MediHelp rates the interaction as minor. Telotristat ethyl and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Telotristat induces CYP3A4 and may reduce exposure to sensitive substrates. Theophylline relies mainly on CYP1A2, so the effect is likely small, though reduced efficacy is possible.
How serious is the interaction between Telotristat ethyl and Theophylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor asthma or COPD control and check a theophylline level if response declines.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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