Drug interactions
Tenofovir disoproxil + Trospium chloride
Severity: Moderate
Tenofovir disoproxil and Trospium chloride: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs undergo active tubular secretion in the kidney, so competition may raise concentrations of either one. Higher trospium levels may increase anticholinergic effects, and higher tenofovir levels may increase renal toxicity.
What this interaction means in plain words
Tenofovir disoproxil and Trospium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for active renal tubular secretion via shared transporters.
What to do
Monitor for anticholinergic effects such as dry mouth, constipation and urinary retention, and monitor renal function; reduce trospium dose if renal function is impaired.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Frequently asked questions
Can I take Tenofovir disoproxil with Trospium chloride?
MediHelp rates the interaction as moderate. Tenofovir disoproxil and Trospium chloride can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs undergo active tubular secretion in the kidney, so competition may raise concentrations of either one. Higher trospium levels may increase anticholinergic effects, and higher tenofovir levels may increase renal toxicity.
How serious is the interaction between Tenofovir disoproxil and Trospium chloride?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as dry mouth, constipation and urinary retention, and monitor renal function; reduce trospium dose if renal function is impaired.
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