Drug interactions
Terbutaline + Yohimbine
Severity: Moderate
Terbutaline and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist that increases noradrenergic outflow, and it can raise blood pressure and heart rate and cause anxiety and tremor. Combined with terbutaline, cardiovascular stimulation may be additive, with a risk of tachycardia and hypertension.
What this interaction means in plain words
Terbutaline and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sympathetic stimulation from increased norepinephrine release (yohimbine) and beta-2 agonism (terbutaline).
What to do
Monitor blood pressure and heart rate and avoid the combination in patients with cardiovascular disease or anxiety disorders. Stop yohimbine if palpitations or marked hypertension develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbutaline
Frequently asked questions
Can I take Terbutaline with Yohimbine?
MediHelp rates the interaction as moderate. Terbutaline and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist that increases noradrenergic outflow, and it can raise blood pressure and heart rate and cause anxiety and tremor. Combined with terbutaline, cardiovascular stimulation may be additive, with a risk of tachycardia and hypertension.
How serious is the interaction between Terbutaline and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and avoid the combination in patients with cardiovascular disease or anxiety disorders. Stop yohimbine if palpitations or marked hypertension develop.
What other medicines interact with Terbutaline?
MediHelp also lists interactions of Terbutaline with, for example, Carvedilol, Droperidol, Fexinidazole. The full list is on the Terbutaline page.
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