Drug interactions
Tesamorelin + Theophylline
Severity: Minor
Tesamorelin and Theophylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tesamorelin is a growth hormone-releasing factor analogue that may alter CYP450 activity through the GH/IGF-1 axis. This could change exposure to CYP substrates such as theophylline, although the evidence is limited and the direction is uncertain.
What this interaction means in plain words
Tesamorelin and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Growth hormone axis stimulation may modulate hepatic CYP450 activity; the effect on theophylline is not well established.
What to do
Monitor theophylline serum levels when tesamorelin is started or stopped and adjust the dose as needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Frequently asked questions
Can I take Tesamorelin with Theophylline?
MediHelp rates the interaction as minor. Tesamorelin and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tesamorelin is a growth hormone-releasing factor analogue that may alter CYP450 activity through the GH/IGF-1 axis. This could change exposure to CYP substrates such as theophylline, although the evidence is limited and the direction is uncertain.
How serious is the interaction between Tesamorelin and Theophylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor theophylline serum levels when tesamorelin is started or stopped and adjust the dose as needed.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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