Drug interactions
Theophylline + Vitamin B6
Severity: Minor
Theophylline and Vitamin B6: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Theophylline has been associated with lower plasma pyridoxal phosphate levels, and B6 deficiency has been reported with chronic use. Clinical consequences are uncertain and are usually minor.
What this interaction means in plain words
Theophylline and Vitamin B6 have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Theophylline belongs to Respiratory; Vitamin B6 belongs to Gastrointestinal Tract.
Why it happens
Theophylline may inhibit pyridoxal kinase, reducing formation of active pyridoxal phosphate.
What to do
No routine action is needed. Consider assessing B6 status if neurological symptoms occur during long-term theophylline use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vitamin B6
- Ethotoin + Vitamin B6 Moderate
- Fosphenytoin + Vitamin B6 Moderate
- Isoniazid + Vitamin B6 Moderate
- Levodopa + Vitamin B6 Moderate
- Penicillamine + Vitamin B6 Moderate
- Phenobarbital + Vitamin B6 Moderate
Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Frequently asked questions
Can I take Theophylline with Vitamin B6?
MediHelp rates the interaction as minor. Theophylline and Vitamin B6 have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Theophylline has been associated with lower plasma pyridoxal phosphate levels, and B6 deficiency has been reported with chronic use. Clinical consequences are uncertain and are usually minor.
How serious is the interaction between Theophylline and Vitamin B6?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Consider assessing B6 status if neurological symptoms occur during long-term theophylline use.
What other medicines interact with Vitamin B6?
MediHelp also lists interactions of Vitamin B6 with, for example, Ethotoin, Fosphenytoin, Isoniazid. The full list is on the Vitamin B6 page.
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