Drug interactions
Tofacitinib + Triamcinolone acetonide injectable
Severity: Moderate
Tofacitinib and Triamcinolone acetonide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroid exposure from injectable triamcinolone adds to the immunosuppression of tofacitinib and may increase infection risk. The effect is smaller with a single local injection than with chronic systemic steroids.
What this interaction means in plain words
Tofacitinib and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression from JAK inhibition and corticosteroid effects on immune cells.
What to do
Use the lowest effective steroid dose and avoid repeated injections where possible. Monitor for infection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Frequently asked questions
Can I take Tofacitinib with Triamcinolone acetonide injectable?
MediHelp rates the interaction as moderate. Tofacitinib and Triamcinolone acetonide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroid exposure from injectable triamcinolone adds to the immunosuppression of tofacitinib and may increase infection risk. The effect is smaller with a single local injection than with chronic systemic steroids.
How serious is the interaction between Tofacitinib and Triamcinolone acetonide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective steroid dose and avoid repeated injections where possible. Monitor for infection.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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