Drug interactions
Tofacitinib + Vincristine liposomal
Severity: Major
Tofacitinib and Vincristine liposomal: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Liposomal vincristine is a cytotoxic chemotherapy that can cause myelosuppression, and combining it with tofacitinib increases infection risk.
What this interaction means in plain words
Tofacitinib and Vincristine liposomal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive immunosuppression and myelosuppression from JAK inhibition and cytotoxic chemotherapy.
What to do
Avoid concurrent use where possible and consider holding tofacitinib during chemotherapy. If combined, monitor blood counts and infection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Frequently asked questions
Can I take Tofacitinib with Vincristine liposomal?
MediHelp rates the interaction as major. Tofacitinib and Vincristine liposomal can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Liposomal vincristine is a cytotoxic chemotherapy that can cause myelosuppression, and combining it with tofacitinib increases infection risk.
How serious is the interaction between Tofacitinib and Vincristine liposomal?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use where possible and consider holding tofacitinib during chemotherapy. If combined, monitor blood counts and infection.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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