Drug interactions
Topiramate + Ulipristal
Severity: Moderate
Topiramate and Ulipristal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topiramate is a weak-to-moderate CYP3A4 inducer at higher doses and may lower ulipristal exposure. This could reduce the effectiveness of emergency contraception and lead to contraceptive failure.
What this interaction means in plain words
Topiramate and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Topiramate induces CYP3A4, increasing the metabolism of ulipristal.
What to do
Consider an alternative emergency contraceptive such as a copper intrauterine device, or levonorgestrel with a possible dose adjustment per local guidance. Advise a pregnancy test if the next period is delayed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Topiramate
Frequently asked questions
Can I take Topiramate with Ulipristal?
MediHelp rates the interaction as moderate. Topiramate and Ulipristal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Topiramate is a weak-to-moderate CYP3A4 inducer at higher doses and may lower ulipristal exposure. This could reduce the effectiveness of emergency contraception and lead to contraceptive failure.
How serious is the interaction between Topiramate and Ulipristal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider an alternative emergency contraceptive such as a copper intrauterine device, or levonorgestrel with a possible dose adjustment per local guidance. Advise a pregnancy test if the next period is delayed.
What other medicines interact with Topiramate?
MediHelp also lists interactions of Topiramate with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Topiramate page.
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