Drug interactions
Trifluoperazine + Venlafaxine
Severity: Moderate
Trifluoperazine and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine may modestly inhibit CYP2D6 and raise trifluoperazine exposure, and both drugs can prolong QT. The combination also carries a small risk of serotonin syndrome or neuroleptic malignant syndrome.
What this interaction means in plain words
Trifluoperazine and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation, mild CYP2D6 inhibition, and combined serotonergic and dopamine-blocking effects.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes. Watch for extrapyramidal symptoms, serotonin toxicity and neuroleptic malignant syndrome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Trifluoperazine and Venlafaxine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Trifluoperazine with Venlafaxine?
MediHelp rates the interaction as moderate. Trifluoperazine and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine may modestly inhibit CYP2D6 and raise trifluoperazine exposure, and both drugs can prolong QT. The combination also carries a small risk of serotonin syndrome or neuroleptic malignant syndrome.
How serious is the interaction between Trifluoperazine and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes. Watch for extrapyramidal symptoms, serotonin toxicity and neuroleptic malignant syndrome.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
