Drug interactions
Valerian + Zolpidem
Severity: Moderate
Valerian and Zolpidem: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Valerian has sedative properties and may add to zolpidem's CNS depression, increasing drowsiness and impaired alertness. Clinical evidence is limited.
What this interaction means in plain words
Valerian and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive sedation, likely via GABAergic activity of valerian constituents.
What to do
Avoid combined use where possible and counsel on drowsiness and driving; stop valerian if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolpidem
Frequently asked questions
Can I take Valerian with Zolpidem?
MediHelp rates the interaction as moderate. Valerian and Zolpidem can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Valerian has sedative properties and may add to zolpidem's CNS depression, increasing drowsiness and impaired alertness. Clinical evidence is limited.
How serious is the interaction between Valerian and Zolpidem?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combined use where possible and counsel on drowsiness and driving; stop valerian if excessive sedation occurs.
What other medicines interact with Zolpidem?
MediHelp also lists interactions of Zolpidem with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Benzhydrocodone / acetaminophen. The full list is on the Zolpidem page.
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