Drug interactions
Venlafaxine + Vorapaxar
Severity: Moderate
Venlafaxine and Vorapaxar: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Venlafaxine impairs platelet serotonin uptake and can increase bleeding tendency, which may add to the antiplatelet action of vorapaxar. This raises the chance of bruising, gastrointestinal bleeding and other hemorrhage.
What this interaction means in plain words
Venlafaxine and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of platelet function: PAR-1 antagonism by vorapaxar plus depletion of platelet serotonin by venlafaxine.
What to do
Monitor for signs of bleeding, particularly with concurrent aspirin or clopidogrel. Review the need for the combination in patients with prior GI bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Frequently asked questions
Can I take Venlafaxine with Vorapaxar?
MediHelp rates the interaction as moderate. Venlafaxine and Vorapaxar can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Venlafaxine impairs platelet serotonin uptake and can increase bleeding tendency, which may add to the antiplatelet action of vorapaxar. This raises the chance of bruising, gastrointestinal bleeding and other hemorrhage.
How serious is the interaction between Venlafaxine and Vorapaxar?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of bleeding, particularly with concurrent aspirin or clopidogrel. Review the need for the combination in patients with prior GI bleeding.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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