Drug interactions
Xylometazoline + Yohimbine
Severity: Moderate
Xylometazoline and Yohimbine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine is an alpha-2 antagonist that increases noradrenergic outflow and can raise blood pressure and heart rate. Xylometazoline is an alpha-agonist vasoconstrictor that may add pressor effects if systemically absorbed. The combination could contribute to hypertension, tachycardia or anxiety.
What this interaction means in plain words
Xylometazoline and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic stimulation from alpha-2 blockade (increased norepinephrine release) and direct alpha-agonist vasoconstriction.
What to do
Monitor blood pressure and heart rate, and keep xylometazoline use brief and at labeled doses. Avoid the combination in patients with uncontrolled hypertension or cardiac disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Xylometazoline
- Selegiline + Xylometazoline Contraindicated
- Ergotamine + Xylometazoline Major
- Isocarboxazid + Xylometazoline Major
- Phenelzine + Xylometazoline Major
- Tranylcypromine + Xylometazoline Major
- Amitriptyline + Xylometazoline Moderate
Frequently asked questions
Can I take Xylometazoline with Yohimbine?
MediHelp rates the interaction as moderate. Xylometazoline and Yohimbine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Yohimbine is an alpha-2 antagonist that increases noradrenergic outflow and can raise blood pressure and heart rate. Xylometazoline is an alpha-agonist vasoconstrictor that may add pressor effects if systemically absorbed. The combination could contribute to hypertension, tachycardia or anxiety.
How serious is the interaction between Xylometazoline and Yohimbine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and keep xylometazoline use brief and at labeled doses. Avoid the combination in patients with uncontrolled hypertension or cardiac disease.
What other medicines interact with Xylometazoline?
MediHelp also lists interactions of Xylometazoline with, for example, Selegiline, Ergotamine, Isocarboxazid. The full list is on the Xylometazoline page.
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