مرجع دارویی
Etuvetidigene autotemcel
Etuvetidigene autotemcel is a medicine in the class miscellaneous.
- گروه دارویی: Miscellaneous
آخرین به‌روزرسانی منابع: US FDA label
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
نکات کلیدی
- گروه دارویی
- Miscellaneous
- شکل‌های دارویی رایج
- آمپول
- نام‌های تجاری
- 1
- کشورها و بازارها
- 1
نحوه اثر
Adds full-length copies of the human WAS cDNA into the patient's hematopoietic stem cells by lentiviral vector transduction. After infusion the modified cells engraft in bone marrow and repopulate the hematopoietic compartment, and their progeny express WAS protein (WASP).
دوز معمول بزرگسالان (خلاصه برچسب)
Wiskott-Aldrich Syndrome: minimum recommended dose 7 × 10 6 CD34 + cells/kg based on body weight at infusion, single-dose intravenous infusion via central venous catheter; maximum volume must remain < 20% of estimated plasma volume
بارداری و شیردهی
- بارداری
- Unsafe One-time gene therapy (own modified stem cells). No data in pregnancy. It must not be given during pregnancy because of the risks of the conditioning chemotherapy. Confirm a negative pregnancy test first; use contraception from stem-cell collection until at least 6 months after the infusion.
- شیردهی
- Unsafe No data on presence in milk. Nearly all patients are boys (X-linked disease). Because of the risks of conditioning chemotherapy, breastfeeding must stop during conditioning; afterwards follow the advice for the conditioning drugs.
عوارض جانبی گزارش‌شده
- Catheter related infection
- Bacterial and viral infections
- Diarrhea
- Vomiting
- Stomatitis
- Liver injury
موارد منع مصرف
- Hypersensitivity to the active substance or to any of the excipients
- Previous HSCT within 6 months prior to treatment, or HSCT with evidence of residual donor cells
- Previous treatment with hematopoietic stem cell gene therapy
چه کسانی باید احتیاط کنند
- Hypersensitivity and infusion-related reactions, including anaphylaxis, may occur due to DMSO; monitor during and after infusion
- Engraftment failure may occur; if so, infuse non-transduced back-up stem cells
- Severe cytopenias occur for several weeks; monitor for at least 8 weeks
بارداری یا شیردهی، بیماری کلیه یا کبد، آلرژی‌ها و هر داروی یا مکمل دیگری را که مصرف می‌کنید به داروساز یا پزشک خود اطلاع دهید.
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا تک‌نگاری کامل Etuvetidigene autotemcel را ببینید: دوزها، بارداری و شیردهی، عوارض جانبی، هشدارها و همه تداخل‌ها.
- Dosing by age, kidney and liver function, and further dose lines
- Paediatric dosing
- How to give it
- Patient counselling points
- IV preparation and dilution
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
داروهای دیگر همین گروه
پرسش‌های متداول
What is Etuvetidigene autotemcel used for?
Etuvetidigene autotemcel is a medicine in the class miscellaneous.
What side effects have been reported with Etuvetidigene autotemcel?
Catheter related infection, Bacterial and viral infections, Diarrhea, Vomiting, Stomatitis, Liver injury.
Can Etuvetidigene autotemcel be taken in pregnancy or while breastfeeding?
Pregnancy: Unsafe. One-time gene therapy (own modified stem cells). No data in pregnancy. It must not be given during pregnancy because of the risks of the conditioning chemotherapy. Confirm a negative pregnancy test first; use contraception from stem-cell collection until at least 6 months after the infusion. Breastfeeding: Unsafe. No data on presence in milk. Nearly all patients are boys (X-linked disease). Because of the risks of conditioning chemotherapy, breastfeeding must stop during conditioning; afterwards follow the advice for the conditioning drugs.
What does Etuvetidigene autotemcel interact with?
MediHelp does not list a checked interaction for Etuvetidigene autotemcel yet. Always tell your pharmacist about every medicine you take.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
