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تداخل‌های دارویی

Alteplase + Caplacizumab

شدت: شدید

Alteplase and Caplacizumab: major interaction.

آخرین به‌روزرسانی

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خلاصه

Caplacizumab blocks von Willebrand factor-mediated platelet adhesion, and thrombolysis with alteplase adds fibrinolytic activity. Together they substantially raise the risk of severe bleeding.

معنای این تداخل به زبان ساده

Alteplase and Caplacizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Alteplase belongs to Cardiovascular; Caplacizumab belongs to Cardiovascular.

سطح شواهد: Moderate

چرا رخ می‌دهد

Additive pharmacodynamic effect of impaired platelet adhesion and plasmin-mediated fibrin breakdown.

اقدام لازم

Avoid concurrent use unless thrombolysis is clearly essential; if so, withhold caplacizumab and monitor closely for bleeding with ready access to supportive care.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Alteplase و Caplacizumab، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Alteplase with Caplacizumab?

MediHelp rates the interaction as major. Alteplase and Caplacizumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Caplacizumab blocks von Willebrand factor-mediated platelet adhesion, and thrombolysis with alteplase adds fibrinolytic activity. Together they substantially raise the risk of severe bleeding.

How serious is the interaction between Alteplase and Caplacizumab?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use unless thrombolysis is clearly essential; if so, withhold caplacizumab and monitor closely for bleeding with ready access to supportive care.

What other medicines interact with Alteplase?

MediHelp also lists interactions of Alteplase with, for example, Defibrotide, Reteplase, Tenecteplase. The full list is on the Alteplase page.

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