تداخل‌های دارویی
Alteplase + Tranexamic acid
شدت: شدید
Alteplase and Tranexamic acid: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Tranexamic acid blocks fibrinolysis and therefore directly opposes the clot-dissolving action of alteplase. This can reduce thrombolytic efficacy, and it is also relevant that tranexamic acid is used to reverse thrombolytic-related bleeding.
معنای این تداخل به زبان ساده
Alteplase and Tranexamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Alteplase belongs to Cardiovascular; Tranexamic acid belongs to Cardiovascular.
چرا رخ می‌دهد
Pharmacodynamic antagonism: tranexamic acid blocks lysine binding sites on plasminogen, preventing plasmin formation and fibrin degradation.
اقدام لازم
Avoid concurrent use when thrombolysis is intended. Use tranexamic acid only deliberately to treat life-threatening alteplase-related bleeding.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Alteplase و Tranexamic acid، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Alteplase
- Alteplase + Defibrotide منع مصرف
- Alteplase + Reteplase منع مصرف
- Alteplase + Tenecteplase منع مصرف
- Acetylsalicylic acid + Alteplase شدید
- Alteplase + Apixaban شدید
- Alteplase + Argatroban شدید
تداخلات دیگر Tranexamic acid
- Dienogest / estradiol valerate + Tranexamic acid منع مصرف
- Ethinyl estradiol-drospirenone + Tranexamic acid منع مصرف
- Ethinyl estradiol-levonorgestrel + Tranexamic acid منع مصرف
- Ethinyl estradiol-norgestimate + Tranexamic acid منع مصرف
- Ethinylestradiol + Tranexamic acid منع مصرف
- Mestranol + Tranexamic acid منع مصرف
پرسش‌های متداول
Can I take Alteplase with Tranexamic acid?
MediHelp rates the interaction as major. Alteplase and Tranexamic acid can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tranexamic acid blocks fibrinolysis and therefore directly opposes the clot-dissolving action of alteplase. This can reduce thrombolytic efficacy, and it is also relevant that tranexamic acid is used to reverse thrombolytic-related bleeding.
How serious is the interaction between Alteplase and Tranexamic acid?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use when thrombolysis is intended. Use tranexamic acid only deliberately to treat life-threatening alteplase-related bleeding.
What other medicines interact with Alteplase?
MediHelp also lists interactions of Alteplase with, for example, Defibrotide, Reteplase, Tenecteplase. The full list is on the Alteplase page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
