تداخل‌های دارویی
Amikacin + Cefotaxime
شدت: متوسط
Amikacin and Cefotaxime: moderate interaction.
آخرین به‌روزرسانی
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خلاصه
Concurrent use of a cephalosporin with an aminoglycoside has been associated with additive kidney injury in some reports, particularly in patients with other risk factors. Aminoglycoside ototoxicity may also be a concern.
معنای این تداخل به زبان ساده
Amikacin and Cefotaxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amikacin belongs to Anti Bacterial; Cefotaxime belongs to Anti Bacterial.
چرا رخ می‌دهد
Additive nephrotoxic potential, with aminoglycoside tubular toxicity possibly being aggravated by cephalosporins.
اقدام لازم
Monitor serum creatinine and amikacin levels during combined therapy, and keep the aminoglycoside course as short as possible. Maintain hydration and avoid other nephrotoxins.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amikacin و Cefotaxime، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Cefotaxime
تداخلات دیگر Amikacin
پرسش‌های متداول
Can I take Amikacin with Cefotaxime?
MediHelp rates the interaction as moderate. Amikacin and Cefotaxime can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of a cephalosporin with an aminoglycoside has been associated with additive kidney injury in some reports, particularly in patients with other risk factors. Aminoglycoside ototoxicity may also be a concern.
How serious is the interaction between Amikacin and Cefotaxime?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and amikacin levels during combined therapy, and keep the aminoglycoside course as short as possible. Maintain hydration and avoid other nephrotoxins.
What other medicines interact with Cefotaxime?
MediHelp also lists interactions of Cefotaxime with, for example, Typhoid vaccine live, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefotaxime page.
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