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Amiodarone + Propranolol

شدت: شدید

Amiodarone and Propranolol: major interaction.

آخرین به‌روزرسانی

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خلاصه

Together these drugs can cause additive bradycardia, sinus arrest and AV block, and amiodarone may also raise propranolol levels. Patients with sinus node dysfunction or conduction disease are at highest risk.

معنای این تداخل به زبان ساده

Amiodarone and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Amiodarone belongs to Cardiovascular; Propranolol belongs to Cardiovascular.

سطح شواهد: High

چرا رخ می‌دهد

Additive negative chronotropic and dromotropic effects, plus amiodarone inhibition of CYP2D6-mediated propranolol metabolism.

اقدام لازم

Monitor ECG and heart rate closely, especially at initiation, and reduce the propranolol dose as needed. Avoid in patients with sick sinus syndrome or AV block unless a pacemaker is in place.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amiodarone و Propranolol، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Amiodarone with Propranolol?

MediHelp rates the interaction as major. Amiodarone and Propranolol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Together these drugs can cause additive bradycardia, sinus arrest and AV block, and amiodarone may also raise propranolol levels. Patients with sinus node dysfunction or conduction disease are at highest risk.

How serious is the interaction between Amiodarone and Propranolol?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and heart rate closely, especially at initiation, and reduce the propranolol dose as needed. Avoid in patients with sick sinus syndrome or AV block unless a pacemaker is in place.

What other medicines interact with Propranolol?

MediHelp also lists interactions of Propranolol with, for example, Thioridazine, Acebutolol, Adrenaline-articaine. The full list is on the Propranolol page.

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