تداخلهای دارویی
Amlodipine-olmesartan-hydrochlorothiazide + Etodolac
شدت: شدید
Amlodipine-olmesartan-hydrochlorothiazide and Etodolac: major interaction.
آخرین بهروزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصهای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمیشود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
NSAIDs such as etodolac can reduce the antihypertensive effect of olmesartan and hydrochlorothiazide. In combination with an ARB and a diuretic they increase the risk of acute kidney injury and hyperkalemia, especially in older or volume-depleted patients.
معنای این تداخل به زبان ساده
Amlodipine-olmesartan-hydrochlorothiazide and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amlodipine-olmesartan-hydrochlorothiazide belongs to Cardiovascular; Etodolac belongs to Musculoskeletal.
چرا رخ میدهد
NSAID inhibition of renal prostaglandin synthesis reduces renal perfusion and sodium excretion, antagonizing antihypertensive effects and impairing renal function.
اقدام لازم
Avoid regular use where possible and prefer paracetamol. If an NSAID is required, use the lowest dose for the shortest time and monitor blood pressure, creatinine and potassium.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیههای کامل مدیریت Amlodipine-olmesartan-hydrochlorothiazide و Etodolac، یادداشتهای تکمیلی، جزئیات شواهد و بررسیکننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۷ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Amlodipine-olmesartan-hydrochlorothiazide
- Aliskiren + Amlodipine-olmesartan-hydrochlorothiazide منع مصرف
- Amlodipine-olmesartan-hydrochlorothiazide + Dofetilide منع مصرف
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan منع مصرف
- Acemetacin + Amlodipine-olmesartan-hydrochlorothiazide شدید
- Aldesleukin + Amlodipine-olmesartan-hydrochlorothiazide شدید
- Amifostine + Amlodipine-olmesartan-hydrochlorothiazide شدید
تداخلات دیگر Etodolac
- Etodolac + Ketorolac منع مصرف
- Etodolac + Ketorolac intranasal منع مصرف
- Aceclofenac + Etodolac شدید
- Acemetacin + Etodolac شدید
- Acetylsalicylic acid + Etodolac شدید
- Alteplase + Etodolac شدید
پرسشهای متداول
Can I take Amlodipine-olmesartan-hydrochlorothiazide with Etodolac?
MediHelp rates the interaction as major. Amlodipine-olmesartan-hydrochlorothiazide and Etodolac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs such as etodolac can reduce the antihypertensive effect of olmesartan and hydrochlorothiazide. In combination with an ARB and a diuretic they increase the risk of acute kidney injury and hyperkalemia, especially in older or volume-depleted patients.
How serious is the interaction between Amlodipine-olmesartan-hydrochlorothiazide and Etodolac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular use where possible and prefer paracetamol. If an NSAID is required, use the lowest dose for the shortest time and monitor blood pressure, creatinine and potassium.
What other medicines interact with Amlodipine-olmesartan-hydrochlorothiazide?
MediHelp also lists interactions of Amlodipine-olmesartan-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Amlodipine-olmesartan-hydrochlorothiazide page.
تکنگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.