تداخل‌های دارویی
Amobarbital + Tinidazole
شدت: متوسط
Amobarbital and Tinidazole: moderate interaction.
آخرین به‌روزرسانی
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خلاصه
Barbiturates induce CYP3A4 and other hepatic enzymes, which can speed tinidazole clearance and lower its concentrations. This may reduce efficacy in infections such as giardiasis or anaerobic infections, although the clinical impact has not been well quantified.
معنای این تداخل به زبان ساده
Amobarbital and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Tinidazole belongs to Anti Parasitic.
چرا رخ می‌دهد
Amobarbital induces hepatic CYP enzymes including CYP3A4, increasing tinidazole metabolism.
اقدام لازم
Monitor for clinical response to tinidazole and consider a longer course or an alternative agent if treatment fails. Be aware that the induction effect persists for some time after the barbiturate is stopped.
از داروساز چه بپرسید
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amobarbital و Tinidazole، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Tinidazole
- Disulfiram + Tinidazole منع مصرف
- Ethanol + Tinidazole شدید
- Fexinidazole + Tinidazole شدید
- Lopinavir + Tinidazole شدید
- Nilotinib + Tinidazole شدید
- Ritonavir + Tinidazole شدید
تداخلات دیگر Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates منع مصرف
- Amobarbital + Doravirine منع مصرف
- Amobarbital + Elbasvir / grazoprevir منع مصرف
- Amobarbital + Isavuconazonium منع مصرف
- Amobarbital + Isocarboxazid منع مصرف
- Amobarbital + Lonafarnib منع مصرف
پرسش‌های متداول
Can I take Amobarbital with Tinidazole?
MediHelp rates the interaction as moderate. Amobarbital and Tinidazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and other hepatic enzymes, which can speed tinidazole clearance and lower its concentrations. This may reduce efficacy in infections such as giardiasis or anaerobic infections, although the clinical impact has not been well quantified.
How serious is the interaction between Amobarbital and Tinidazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clinical response to tinidazole and consider a longer course or an alternative agent if treatment fails. Be aware that the induction effect persists for some time after the barbiturate is stopped.
What other medicines interact with Tinidazole?
MediHelp also lists interactions of Tinidazole with, for example, Disulfiram, Ethanol, Fexinidazole. The full list is on the Tinidazole page.
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