تداخل‌های دارویی
Amoxapine + Phenelzine
شدت: منع مصرف
Amoxapine and Phenelzine: contraindicated interaction.
آخرین به‌روزرسانی
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Combining an MAO inhibitor with amoxapine, which inhibits monoamine reuptake, can cause serotonin syndrome and hypertensive crises. Severe reactions including hyperthermia and seizures have been described with antidepressant-MAOI combinations.
معنای این تداخل به زبان ساده
Amoxapine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
چرا رخ می‌دهد
MAO inhibition combined with reuptake inhibition causes excess synaptic serotonin and norepinephrine.
اقدام لازم
Do not combine; allow at least 14 days after stopping phenelzine before starting amoxapine, and an adequate washout after stopping amoxapine before phenelzine.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amoxapine و Phenelzine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Phenelzine
- 5-HTP + Phenelzine منع مصرف
- Amitriptyline + Phenelzine منع مصرف
- Atomoxetine + Phenelzine منع مصرف
- Benzphetamine + Phenelzine منع مصرف
- Brimonidine + Phenelzine منع مصرف
- Buprenorphine long-acting + Phenelzine منع مصرف
پرسش‌های متداول
Can I take Amoxapine with Phenelzine?
MediHelp rates the interaction as contraindicated. Amoxapine and Phenelzine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Combining an MAO inhibitor with amoxapine, which inhibits monoamine reuptake, can cause serotonin syndrome and hypertensive crises. Severe reactions including hyperthermia and seizures have been described with antidepressant-MAOI combinations.
How serious is the interaction between Amoxapine and Phenelzine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine; allow at least 14 days after stopping phenelzine before starting amoxapine, and an adequate washout after stopping amoxapine before phenelzine.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Atomoxetine. The full list is on the Phenelzine page.
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