تداخل‌های دارویی
Amoxapine + Procarbazine
شدت: منع مصرف
Amoxapine and Procarbazine: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Procarbazine has monoamine oxidase inhibitor activity, and amoxapine is a tricyclic antidepressant that inhibits noradrenaline and serotonin reuptake. Together they can cause serotonin syndrome or hypertensive reactions, with agitation, hyperthermia, autonomic instability and seizures.
معنای این تداخل به زبان ساده
Amoxapine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
چرا رخ می‌دهد
MAO inhibition combined with reuptake inhibition raises synaptic monoamine concentrations, with additive serotonergic and adrenergic effects.
اقدام لازم
Avoid the combination. Leave a washout period of at least 14 days after stopping procarbazine before starting amoxapine, and the reverse as well.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amoxapine و Procarbazine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine منع مصرف
- Amitriptyline + Procarbazine منع مصرف
- Atomoxetine + Procarbazine منع مصرف
- Bcg vaccine live + Procarbazine منع مصرف
- Brimonidine + Procarbazine منع مصرف
- Buspirone + Procarbazine منع مصرف
پرسش‌های متداول
Can I take Amoxapine with Procarbazine?
MediHelp rates the interaction as contraindicated. Amoxapine and Procarbazine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine has monoamine oxidase inhibitor activity, and amoxapine is a tricyclic antidepressant that inhibits noradrenaline and serotonin reuptake. Together they can cause serotonin syndrome or hypertensive reactions, with agitation, hyperthermia, autonomic instability and seizures.
How serious is the interaction between Amoxapine and Procarbazine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. Leave a washout period of at least 14 days after stopping procarbazine before starting amoxapine, and the reverse as well.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Atomoxetine. The full list is on the Procarbazine page.
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