تداخل‌های دارویی
Amphotericin b + Tobramycin
شدت: شدید
Amphotericin b and Tobramycin: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Both drugs are nephrotoxic, and tobramycin is also ototoxic and vestibulotoxic. Combined use raises the risk of acute kidney injury, which in turn increases aminoglycoside accumulation and the risk of permanent hearing or balance damage.
معنای این تداخل به زبان ساده
Amphotericin b and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Amphotericin b belongs to Anti Fungals; Tobramycin belongs to Anti Bacterial.
چرا رخ می‌دهد
Additive nephrotoxicity from renal tubular injury, with reduced aminoglycoside clearance amplifying ototoxicity.
اقدام لازم
Avoid the combination if an alternative exists. If it is necessary, monitor serum creatinine, electrolytes and tobramycin levels frequently, ensure hydration, and consider a lipid-based amphotericin formulation.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Amphotericin b و Tobramycin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Amphotericin b
تداخلات دیگر Tobramycin
پرسش‌های متداول
Can I take Amphotericin b with Tobramycin?
MediHelp rates the interaction as major. Amphotericin b and Tobramycin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs are nephrotoxic, and tobramycin is also ototoxic and vestibulotoxic. Combined use raises the risk of acute kidney injury, which in turn increases aminoglycoside accumulation and the risk of permanent hearing or balance damage.
How serious is the interaction between Amphotericin b and Tobramycin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if an alternative exists. If it is necessary, monitor serum creatinine, electrolytes and tobramycin levels frequently, ensure hydration, and consider a lipid-based amphotericin formulation.
What other medicines interact with Amphotericin b?
MediHelp also lists interactions of Amphotericin b with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Amphotericin b page.
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