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تداخل‌های دارویی

Argatroban + Ketorolac

شدت: منع مصرف

Argatroban and Ketorolac: contraindicated interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Ketorolac inhibits platelet function and can cause gastrointestinal ulceration, while argatroban is a direct thrombin inhibitor, so bleeding risk is substantially increased. Ketorolac labeling contraindicates its use in patients at risk of bleeding and with concurrent anticoagulants.

معنای این تداخل به زبان ساده

Argatroban and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.

Argatroban belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.

سطح شواهد: Moderate

چرا رخ می‌دهد

Additive hemostatic impairment from NSAID-mediated platelet inhibition and direct thrombin inhibition.

اقدام لازم

Avoid ketorolac in patients receiving argatroban and use a non-NSAID analgesic such as paracetamol or an appropriate alternative; monitor for bleeding if exposure has occurred.

از داروساز چه بپرسید

  • Is there an alternative to one of these two medicines for me?
  • If both are essential, who is monitoring me and how often?
  • Which symptoms mean I should stop and seek help straight away?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Argatroban و Ketorolac، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Argatroban with Ketorolac?

MediHelp rates the interaction as contraindicated. Argatroban and Ketorolac are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ketorolac inhibits platelet function and can cause gastrointestinal ulceration, while argatroban is a direct thrombin inhibitor, so bleeding risk is substantially increased. Ketorolac labeling contraindicates its use in patients at risk of bleeding and with concurrent anticoagulants.

How serious is the interaction between Argatroban and Ketorolac?

MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ketorolac in patients receiving argatroban and use a non-NSAID analgesic such as paracetamol or an appropriate alternative; monitor for bleeding if exposure has occurred.

What other medicines interact with Ketorolac?

MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.

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