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تداخل‌های دارویی

Aripiprazole + Mitotane

شدت: شدید

Aripiprazole and Mitotane: major interaction.

آخرین به‌روزرسانی

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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Mitotane is a strong CYP3A4 inducer and can substantially lower aripiprazole concentrations, risking loss of psychiatric control. The induction can persist for weeks after mitotane is stopped.

معنای این تداخل به زبان ساده

Aripiprazole and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Aripiprazole belongs to Central Nervous System; Mitotane belongs to Oncology.

سطح شواهد: Moderate

چرا رخ می‌دهد

Induction of CYP3A4 increases aripiprazole clearance.

اقدام لازم

Aripiprazole labeling advises roughly doubling the dose with strong CYP3A4 inducers; titrate by clinical response. Reduce the dose again if mitotane is discontinued.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Aripiprazole و Mitotane، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Aripiprazole with Mitotane?

MediHelp rates the interaction as major. Aripiprazole and Mitotane can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Mitotane is a strong CYP3A4 inducer and can substantially lower aripiprazole concentrations, risking loss of psychiatric control. The induction can persist for weeks after mitotane is stopped.

How serious is the interaction between Aripiprazole and Mitotane?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Aripiprazole labeling advises roughly doubling the dose with strong CYP3A4 inducers; titrate by clinical response. Reduce the dose again if mitotane is discontinued.

What other medicines interact with Aripiprazole?

MediHelp also lists interactions of Aripiprazole with, for example, Pimozide, Thioridazine, Amisulpride. The full list is on the Aripiprazole page.

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