تداخل‌های دارویی
Azithromycin + Piperaquine
شدت: منع مصرف
Azithromycin and Piperaquine: contraindicated interaction.
آخرین به‌روزرسانی منابع: US FDA label
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Piperaquine, given as dihydroartemisinin-piperaquine, causes dose-related QTc prolongation, and azithromycin is also associated with QT prolongation and torsades de pointes. Combined use may produce additive effects with a risk of serious ventricular arrhythmia. The Eurartesim SmPC contraindicates use with other medicines that prolong the QT interval, including macrolide antibiotics.
معنای این تداخل به زبان ساده
Azithromycin and Piperaquine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
چرا رخ می‌دهد
Additive pharmacodynamic QT prolongation through IKr (hERG) potassium channel blockade; piperaquine also has a very long elimination half-life, prolonging the period of exposure.
اقدام لازم
Do not co-administer; choose an antibiotic without QT liability or an antimalarial without piperaquine if azithromycin is essential. Avoid starting azithromycin for several weeks after piperaquine because of its long half-life.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Azithromycin و Piperaquine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
منابع
- Eurartesim (dihydroartemisinin/piperaquine phosphate) Summary of Product Characteristics - Contraindications and Interactions — EMA SmPC
- Zithromax (azithromycin) Prescribing Information - QT Prolongation — FDA Label
تداخلات دیگر Azithromycin
- Azithromycin + Cisapride منع مصرف
- Azithromycin + Domperidone منع مصرف
- Azithromycin + Dronedarone منع مصرف
- Azithromycin + Pimozide منع مصرف
- Azithromycin + Thioridazine منع مصرف
- Adagrasib + Azithromycin شدید
پرسش‌های متداول
Can I take Azithromycin with Piperaquine?
MediHelp rates the interaction as contraindicated. Azithromycin and Piperaquine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Piperaquine, given as dihydroartemisinin-piperaquine, causes dose-related QTc prolongation, and azithromycin is also associated with QT prolongation and torsades de pointes. Combined use may produce additive effects with a risk of serious ventricular arrhythmia. The Eurartesim SmPC contraindicates use with other medicines that prolong the QT interval, including macrolide antibiotics.
How serious is the interaction between Azithromycin and Piperaquine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not co-administer; choose an antibiotic without QT liability or an antimalarial without piperaquine if azithromycin is essential. Avoid starting azithromycin for several weeks after piperaquine because of its long half-life.
What other medicines interact with Azithromycin?
MediHelp also lists interactions of Azithromycin with, for example, Cisapride, Domperidone, Dronedarone. The full list is on the Azithromycin page.
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