تداخل‌های دارویی
Bazedoxifene-conjugated estrogens + Dalteparin
شدت: شدید
Bazedoxifene-conjugated estrogens and Dalteparin: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Conjugated estrogens and bazedoxifene both raise the risk of venous thromboembolism, which is exactly what dalteparin is given to prevent or treat. The prothrombotic estrogen effect may undermine anticoagulation, and the combination is generally inappropriate in active or prior VTE.
معنای این تداخل به زبان ساده
Bazedoxifene-conjugated estrogens and Dalteparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bazedoxifene-conjugated estrogens belongs to Endocrine; Dalteparin belongs to Cardiovascular.
چرا رخ می‌دهد
Estrogen and SERM-related prothrombotic changes (increased clotting factors, reduced antithrombin) counteract anticoagulant effect
اقدام لازم
Avoid the estrogen/bazedoxifene combination in patients needing therapeutic anticoagulation for VTE; if prophylactic anticoagulation overlaps, reassess the need for hormone therapy.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Bazedoxifene-conjugated estrogens و Dalteparin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Bazedoxifene-conjugated estrogens
- Anastrozole + Bazedoxifene-conjugated estrogens منع مصرف
- Bazedoxifene-conjugated estrogens + Ospemifene منع مصرف
- Antithrombin alfa + Bazedoxifene-conjugated estrogens شدید
- Antithrombin iii + Bazedoxifene-conjugated estrogens شدید
- Bazedoxifene-conjugated estrogens + Bemiparin شدید
- Bazedoxifene-conjugated estrogens + Carbamazepine شدید
تداخلات دیگر Dalteparin
- Dalteparin + Defibrotide منع مصرف
- Dalteparin + Ketorolac منع مصرف
- Dalteparin + Mifepristone منع مصرف
- Abciximab + Dalteparin شدید
- Acalabrutinib + Dalteparin شدید
- Aceclofenac + Dalteparin شدید
پرسش‌های متداول
Can I take Bazedoxifene-conjugated estrogens with Dalteparin?
MediHelp rates the interaction as major. Bazedoxifene-conjugated estrogens and Dalteparin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Conjugated estrogens and bazedoxifene both raise the risk of venous thromboembolism, which is exactly what dalteparin is given to prevent or treat. The prothrombotic estrogen effect may undermine anticoagulation, and the combination is generally inappropriate in active or prior VTE.
How serious is the interaction between Bazedoxifene-conjugated estrogens and Dalteparin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the estrogen/bazedoxifene combination in patients needing therapeutic anticoagulation for VTE; if prophylactic anticoagulation overlaps, reassess the need for hormone therapy.
What other medicines interact with Bazedoxifene-conjugated estrogens?
MediHelp also lists interactions of Bazedoxifene-conjugated estrogens with, for example, Anastrozole, Ospemifene, Antithrombin alfa. The full list is on the Bazedoxifene-conjugated estrogens page.
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