تداخل‌های دارویی
Brexanolone + Diazepam
شدت: شدید
Brexanolone and Diazepam: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Brexanolone causes dose-related sedation and sudden loss of consciousness, and other CNS depressants such as diazepam may add to these effects. The combination increases the risk of excessive sedation and impaired responsiveness during the infusion.
معنای این تداخل به زبان ساده
Brexanolone and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
چرا رخ می‌دهد
Additive CNS depression, as both drugs positively modulate GABA-A receptors.
اقدام لازم
Monitor continuously for sedation and hypoxia during the infusion, and reduce or interrupt the infusion if excessive sedation occurs. Review whether the benzodiazepine is needed during treatment.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Brexanolone و Diazepam، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Diazepam
پرسش‌های متداول
Can I take Brexanolone with Diazepam?
MediHelp rates the interaction as major. Brexanolone and Diazepam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Brexanolone causes dose-related sedation and sudden loss of consciousness, and other CNS depressants such as diazepam may add to these effects. The combination increases the risk of excessive sedation and impaired responsiveness during the infusion.
How serious is the interaction between Brexanolone and Diazepam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor continuously for sedation and hypoxia during the infusion, and reduce or interrupt the infusion if excessive sedation occurs. Review whether the benzodiazepine is needed during treatment.
What other medicines interact with Diazepam?
MediHelp also lists interactions of Diazepam with, for example, Calcium / magnesium / potassium / sodium oxybates, Alfentanil, Alprazolam. The full list is on the Diazepam page.
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