تداخل‌های دارویی
Brimonidine + Tranylcypromine
شدت: منع مصرف
Brimonidine and Tranylcypromine: contraindicated interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Brimonidine labelling forbids use with MAO inhibitors, and tranylcypromine is an irreversible non-selective MAO inhibitor. Systemic absorption of the alpha-2 agonist could lead to unpredictable blood-pressure changes, and the effect on catecholamine handling is poorly characterised.
معنای این تداخل به زبان ساده
Brimonidine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Brimonidine belongs to Miscellaneous; Tranylcypromine belongs to Central Nervous System.
چرا رخ می‌دهد
Uncertain: MAO inhibition may alter handling of circulating amines and potentiate systemic alpha-2 agonist cardiovascular effects
اقدام لازم
Avoid brimonidine in patients taking tranylcypromine; use a different intraocular-pressure-lowering agent such as a prostaglandin analogue or beta-blocker where appropriate.
از داروساز چه بپرسید
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Brimonidine و Tranylcypromine، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Tranylcypromine
- 5-HTP + Tranylcypromine منع مصرف
- Amitriptyline + Tranylcypromine منع مصرف
- Amoxapine + Tranylcypromine منع مصرف
- Atomoxetine + Tranylcypromine منع مصرف
- Benzphetamine + Tranylcypromine منع مصرف
- Buprenorphine long-acting + Tranylcypromine منع مصرف
تداخلات دیگر Brimonidine
- Brimonidine + Isocarboxazid منع مصرف
- Brimonidine + Linezolid منع مصرف
- Brimonidine + Phenelzine منع مصرف
- Brimonidine + Procarbazine منع مصرف
- Brimonidine + Rasagiline منع مصرف
- Brimonidine + Selegiline منع مصرف
پرسش‌های متداول
Can I take Brimonidine with Tranylcypromine?
MediHelp rates the interaction as contraindicated. Brimonidine and Tranylcypromine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Brimonidine labelling forbids use with MAO inhibitors, and tranylcypromine is an irreversible non-selective MAO inhibitor. Systemic absorption of the alpha-2 agonist could lead to unpredictable blood-pressure changes, and the effect on catecholamine handling is poorly characterised.
How serious is the interaction between Brimonidine and Tranylcypromine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid brimonidine in patients taking tranylcypromine; use a different intraocular-pressure-lowering agent such as a prostaglandin analogue or beta-blocker where appropriate.
What other medicines interact with Tranylcypromine?
MediHelp also lists interactions of Tranylcypromine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Tranylcypromine page.
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