تداخلهای دارویی
Buprenorphine + Chlordiazepoxide-clidinium
شدت: شدید
Buprenorphine and Chlordiazepoxide-clidinium: major interaction.
آخرین بهروزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصهای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمیشود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Benzodiazepines combined with opioids such as buprenorphine can cause profound sedation, respiratory depression, coma and death. Regulators have issued boxed warnings for this class combination.
معنای این تداخل به زبان ساده
Buprenorphine and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Buprenorphine belongs to Musculoskeletal; Chlordiazepoxide-clidinium belongs to Gastrointestinal Tract.
چرا رخ میدهد
Additive CNS and respiratory depression via opioid and GABA-A receptor effects.
اقدام لازم
Avoid the combination when possible; if necessary, use the lowest doses for the shortest duration. Monitor respiratory rate and sedation and counsel patients and caregivers about warning signs.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیههای کامل مدیریت Buprenorphine و Chlordiazepoxide-clidinium، یادداشتهای تکمیلی، جزئیات شواهد و بررسیکننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Chlordiazepoxide-clidinium
تداخلات دیگر Buprenorphine
- Alvimopan + Buprenorphine منع مصرف
- Buprenorphine + Calcium / magnesium / potassium / sodium oxybates منع مصرف
- Buprenorphine + Olanzapine / samidorphan منع مصرف
- Buprenorphine + Phenelzine منع مصرف
- Buprenorphine + Pimozide منع مصرف
- Buprenorphine + Thioridazine منع مصرف
پرسشهای متداول
Can I take Buprenorphine with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as major. Buprenorphine and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzodiazepines combined with opioids such as buprenorphine can cause profound sedation, respiratory depression, coma and death. Regulators have issued boxed warnings for this class combination.
How serious is the interaction between Buprenorphine and Chlordiazepoxide-clidinium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination when possible; if necessary, use the lowest doses for the shortest duration. Monitor respiratory rate and sedation and counsel patients and caregivers about warning signs.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
تکنگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.