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تداخل‌های دارویی

Buprenorphine + Methohexital

شدت: شدید

Buprenorphine and Methohexital: major interaction.

آخرین به‌روزرسانی

ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.

محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.

خلاصه

Methohexital is a barbiturate anesthetic, and with an opioid it produces additive CNS and respiratory depression. Hypotension, profound sedation and apnea may occur.

معنای این تداخل به زبان ساده

Buprenorphine and Methohexital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.

Buprenorphine belongs to Musculoskeletal; Methohexital belongs to Central Nervous System.

سطح شواهد: High

چرا رخ می‌دهد

Additive CNS and respiratory depression from opioid and barbiturate effects.

اقدام لازم

Titrate methohexital carefully with reduced doses and ensure continuous monitoring of respiration, oxygenation and blood pressure. Have airway support and resuscitation equipment ready.

از داروساز چه بپرسید

  • Does the benefit of taking both outweigh the risk in my case?
  • Do I need any blood test, ECG or other check while on both?
  • What early warning signs should I watch for, and what should I do if they appear?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

ویژه اعضای Pro+

باز کردن کل صفحه

یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Buprenorphine و Methohexital، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.

  • Full clinical management advice
  • Additional notes
  • Evidence detail
  • Interaction checker for a whole prescription

Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.

پرسش‌های متداول

Can I take Buprenorphine with Methohexital?

MediHelp rates the interaction as major. Buprenorphine and Methohexital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Methohexital is a barbiturate anesthetic, and with an opioid it produces additive CNS and respiratory depression. Hypotension, profound sedation and apnea may occur.

How serious is the interaction between Buprenorphine and Methohexital?

MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital carefully with reduced doses and ensure continuous monitoring of respiration, oxygenation and blood pressure. Have airway support and resuscitation equipment ready.

What other medicines interact with Buprenorphine?

MediHelp also lists interactions of Buprenorphine with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Olanzapine / samidorphan. The full list is on the Buprenorphine page.

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