تداخل‌های دارویی
Buprenorphine long-acting + Chlordiazepoxide-clidinium
شدت: شدید
Buprenorphine long-acting and Chlordiazepoxide-clidinium: major interaction.
آخرین به‌روزرسانی
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محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Long-acting injectable buprenorphine with chlordiazepoxide can cause profound sedation, respiratory depression, coma and death. Exposure persists for weeks and cannot be rapidly reversed.
معنای این تداخل به زبان ساده
Buprenorphine long-acting and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
چرا رخ می‌دهد
Additive CNS and respiratory depression from opioid and benzodiazepine effects.
اقدام لازم
Use only when alternatives are inadequate, and keep benzodiazepine doses minimal and short. Monitor for sedation and respiratory depression.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Buprenorphine long-acting و Chlordiazepoxide-clidinium، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Chlordiazepoxide-clidinium
پرسش‌های متداول
Can I take Buprenorphine long-acting with Chlordiazepoxide-clidinium?
MediHelp rates the interaction as major. Buprenorphine long-acting and Chlordiazepoxide-clidinium can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Long-acting injectable buprenorphine with chlordiazepoxide can cause profound sedation, respiratory depression, coma and death. Exposure persists for weeks and cannot be rapidly reversed.
How serious is the interaction between Buprenorphine long-acting and Chlordiazepoxide-clidinium?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only when alternatives are inadequate, and keep benzodiazepine doses minimal and short. Monitor for sedation and respiratory depression.
What other medicines interact with Chlordiazepoxide-clidinium?
MediHelp also lists interactions of Chlordiazepoxide-clidinium with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Chlordiazepoxide-clidinium page.
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