تداخل‌های دارویی
Buprenorphine long-acting + Orphenadrin
شدت: شدید
Buprenorphine long-acting and Orphenadrin: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
Orphenadrine is sedating and anticholinergic, and long-acting injectable buprenorphine provides sustained opioid exposure. The combination may cause additive sedation and respiratory depression that persists because buprenorphine cannot be quickly withdrawn.
معنای این تداخل به زبان ساده
Buprenorphine long-acting and Orphenadrin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
چرا رخ می‌دهد
Additive CNS depression.
اقدام لازم
Use only if alternatives are inadequate and keep the orphenadrine dose and duration to a minimum. Monitor for sedation and slowed breathing.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Buprenorphine long-acting و Orphenadrin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Orphenadrin
پرسش‌های متداول
Can I take Buprenorphine long-acting with Orphenadrin?
MediHelp rates the interaction as major. Buprenorphine long-acting and Orphenadrin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Orphenadrine is sedating and anticholinergic, and long-acting injectable buprenorphine provides sustained opioid exposure. The combination may cause additive sedation and respiratory depression that persists because buprenorphine cannot be quickly withdrawn.
How serious is the interaction between Buprenorphine long-acting and Orphenadrin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if alternatives are inadequate and keep the orphenadrine dose and duration to a minimum. Monitor for sedation and slowed breathing.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
