تداخل‌های دارویی
Cannabidiol + Phenytoin
شدت: شدید
Cannabidiol and Phenytoin: major interaction.
آخرین به‌روزرسانی
ویژه کادر درمان — فقط جهت مرجع. این صفحه خلاصه‌ای کوتاه است، توصیه پزشکی نیست و جایگزین بروشور رسمی یا قضاوت بالینی نمی‌شود. پیش از تجویز یا تحویل دارو همیشه بررسی کنید.
محتوای بالینی این صفحه فقط به زبان انگلیسی موجود است.
خلاصه
The interaction runs in both directions. Phenytoin may lower cannabidiol exposure through CYP3A4 induction, reducing seizure control. Cannabidiol may raise phenytoin concentrations through inhibition of CYP2C19 and CYP2C9, which can lead to phenytoin toxicity given its narrow therapeutic index.
معنای این تداخل به زبان ساده
Cannabidiol and Phenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Cannabidiol belongs to Central Nervous System; Phenytoin belongs to Central Nervous System.
چرا رخ می‌دهد
Phenytoin induces CYP3A4 and CYP2C19 metabolism of cannabidiol, while cannabidiol inhibits CYP2C19 and CYP2C9 metabolism of phenytoin.
اقدام لازم
Monitor phenytoin serum levels and signs of toxicity such as nystagmus, ataxia and sedation when cannabidiol is started or changed, and reduce the phenytoin dose as needed. Consider raising the cannabidiol dose according to response and tolerability.
از داروساز چه بپرسید
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
ویژه اعضای Pro+
باز کردن کل صفحه
یک حساب بسازید و دوره آزمایشی Pro+ را شروع کنید تا توصیه‌های کامل مدیریت Cannabidiol و Phenytoin، یادداشت‌های تکمیلی، جزئیات شواهد و بررسی‌کننده تداخل برای کل نسخه را باز کنید.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Pro+ را ۱۴ روز رایگان در وب امتحان کنید. بدون نیاز به کارت.
تداخلات دیگر Phenytoin
- Artemether / lumefantrine + Phenytoin منع مصرف
- Bictegravir + Phenytoin منع مصرف
- Cabotegravir + Phenytoin منع مصرف
- Doravirine + Phenytoin منع مصرف
- Elbasvir / grazoprevir + Phenytoin منع مصرف
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin منع مصرف
تداخلات دیگر Cannabidiol
پرسش‌های متداول
Can I take Cannabidiol with Phenytoin?
MediHelp rates the interaction as major. Cannabidiol and Phenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The interaction runs in both directions. Phenytoin may lower cannabidiol exposure through CYP3A4 induction, reducing seizure control. Cannabidiol may raise phenytoin concentrations through inhibition of CYP2C19 and CYP2C9, which can lead to phenytoin toxicity given its narrow therapeutic index.
How serious is the interaction between Cannabidiol and Phenytoin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor phenytoin serum levels and signs of toxicity such as nystagmus, ataxia and sedation when cannabidiol is started or changed, and reduce the phenytoin dose as needed. Consider raising the cannabidiol dose according to response and tolerability.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
تک‌نگاری کامل، دوزاژ و بررسی تداخل دارویی در برنامه MediHelp
مرجع کامل را باز کنید، تداخل چند دارو را بررسی کنید و از ابزارهای دوز در برنامه MediHelp استفاده کنید.
